SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-Cell Stage and Become Segregated to the TE in the Mouse Blastocyst＝＝＝
SNAI1 and SNAI2 are transcription factors that initiate Epithelial-to-Mesenchymal cell transitions throughout development and in cancer metastasis. Here we show novel expression of SNAI1 and SNAI2 throughout mouse preimplantation development revealing asymmetrical localization of both SNAI1 and SNAI2 in individual blastomeres beginning at the 2-cell stage through to the 8-cell stage where SNAI1 and SNAI2 are then only detected in outer cells and not inner cells of the blastocyst. This study implicates SNAI1 and SNAI2 in the lineage segregation of the trophectoderm and inner cell mass, and provides new insight into these oncogenes.
Trophectoderm(TE)の分化に重要？な転写因子であるSNAI1/2の発現パターンを見た論文。
予備知識として、
SNAI1/2→E-cadherin/Na-K ATPase→TE
SNAI1KO→neural crestの発育以上
SNAI2KO→survive at birth
compensatoryなメカニズムか？
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